CLASTOGENICITY OF LABORATORY MIXTURE OF LINDANE AND CARBARYL IN MICE

Abstract

A laboratory mixture of two insecticides, viz., carbaryl and lindane (1:1) was tested for its clastogenicity qt the bone marrow erythrocytes of swiss albino mice. The insecticidal mixture was injected intraperitoneally at three dose levels as a suspension in 1% gum acacia, and chromosome aberrations assay and micronucleus test were performed in both sexes separately. Ethylmethanesulphonate (EMS) was taken as positive reference mutagen. An increase in the frequency of micronucleated erythrocytes was observed following treatment with the test chemical mixture.· In chromosome aberrations assay, a significant induction was observed at 185 mglkg bw. at 24h post-treatment time. The female mice appear more tolerant to the test mixture than the male mice.